The year is 1868; English nobleman George Joestar and his son Jonathan become indebted to Dario Brando after being rescued from a carriage incident. What the Joestars don't realize, however, is that Dario had no intention of helping them; he believed they were dead and was trying to ransack their belongings. After Dario's death 12 years later, George—hoping to repay his debt—adopts his son, Dio. While he publicly fawns over his new father, Dio secretly plans to steal the Joestar fortune. His first step is to create a divide between George and Jonathan. By constantly outdoing his foster brother, Dio firmly makes his place in the Joestar family. But when Dio pushes Jonathan too far, Jonathan defeats him in a brawl. Years later, the two appear to be close friends to the outside world. But trouble brews again when George falls ill, as Jonathan suspects that Dio is somehow behind the incident—and it appears he has more tricks up his sleeve.

JoJo no Kimyou na Bouken was announced on July 5, 2012 at a press conference celebrating the 25th anniversary Hirohiko Araki's long-running series. The anime is a full adaptation of the first two parts in the series, Phantom Blood and Sentou Chouryuu (Battle Tendency). While the animation was produced by David Production, the opening theme animations were produced by the studio Kamikaze Douga (神風動画).