Takao Kasuga, a high school student fascinated by poetry, reveres Charles Baudelaire and even decorates his room with the poet's portrait. On a normal day, Takao forgets his copy of The Flowers of Evil in the classroom. When returning to retrieve it, he steals the sports garments of Nanako Saeki—a model student who Takao calls his muse and a femme fatale. Deeply ashamed of his act which he sees as a sin and what others see as a crime, Takao realizes with horror that Sawa Nakamura, his classmate and social outcast, knows about his theft. Blackmailed by her, Takao is now forced to partake in Sawa's disturbing fantasies, lest she reveals his deeds to everyone. Caught in a negative spiral of increasingly traumatic experiences, will Takao be able to break free from Sawa's thorns and atone for his sins?

Aku no Hana is considered to be the first anime to extensively use rotoscoping. The anime adapts the first 20 chapters of the manga. The series was released on Blu-ray and DVD in Japan from August 21, 2013, to December 25, 2013, and in North America by Sentai Filmworks on July 8, 2014.